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Blood presence in apical surgery can prevent the correct vision of the surgical field, change the physical properties of filling materials and reduce their sealing ability. Objectives: To describe which are the most effective and safest haemostatic agents to control bleeding in patients undergoing apical surgery. Material and Methods. We carried out a systematic review, using Medline and Cochrane Library databases, of human clinical studies published in the last 10 years. Results: The agentsdoi:10.4317/medoral.21109 fatcat:ylupqb4w7vfnrf2syvdj4pzxsa