Administration of doxycycline hydrochloride via drinking water to turkeys under laboratory and field conditions

M. D. Santos, H. Vermeersch, J. P. Remon, M. Schelkens, P. De Backer, R. Ducatelle, F. Haesebrouck
1997 Poultry Science  
A series of experiments were carried out in order to determine doxycycline hydrochloride (DoxHCl) plasma levels in 6-wk-old turkeys medicated via drinking water containing DoxHCl at a concentration of 250 mg/L under laboratory and field conditions. Maximal plasma concentration (C max ) values of 5.7 (± 1.0) mg/mL and 4.9 (± 1.4) mg/mL obtained after DoxHCl administration during 2 and 7 d, respectively, were not significantly different. A significant difference was found between the area under
more » ... en the area under the plasma concentration-time profile, calculated between 0 and 168 h (AUC (0-168) ), C max , and the minimal plasma concentration (C min ) values obtained after medication with a DoxHCl solution at a concentration of 250 mg/L (431.9 ± 96.6 mg·h/mL, 4.9 ± 1.4 mg/mL and 0.7 ± 0.3 mg/mL) and after medication with a DoxHCl solution at a concentration of 750 mg/L (1,176.5 ± 201.8 mg·h/mL, 12.5 ± 2.7 mg/mL and 2.9 ± 0.4 mg/mL), respectively. The increase in body weight was also significantly higher for turkeys medicated with a DoxHCl solution at a concentration of 750 mg/L (83.7 g/d) than for the lower concentration (35.6 g/d). The DoxHCl solution uptake significantly decreased with the increase of DoxHCl concentration. A C max value of 1.7 ± 0.6 mg/mL and a C min value of 0.5 ± 0.1 mg/mL were observed during the field experiment. Water consumption under laboratory conditions was followed for tap water (70 ± 50 mL/kg·d) and for a DoxHCl solution at a concentration of 250 mg/L supplemented with 1 g anhydrous citric acid/L (119 ± 6 mL/kg·d) and revealed to be not significantly different. The variability was significantly higher for tap water than for the DoxHCl solution. The stability of the DoxHCl solution containing 1 g citric acid/L over 24 h was 99% expressed as the percentage of the initial concentration. (
doi:10.1093/ps/76.10.1342 pmid:9316108 fatcat:6hloudnze5geznctkde2yhldbe