To study the variants of the clinical course of varicose disease of patients with different grades of connective tissue dysplasia intensity. The results of the examination and treatment of 280 patients with various forms of varicose disease have been studied. The degree (grade) of connective tissue dysplasia intensity has been estimated. The values characterizing flow and coagulation properties of blood, functional activity of thrombocytes have been studied. Morphological, histological,

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... mical check studies of extirpated varicose modified veins of patients with various grades of connective tissue dysplasia intensity have been held. The conducted check studies have shown that lower limbs varicose disease of patients with evident connective tissue dysplasia is characterized by early evidence of clinical signs, rapid advance of the disease, widely spread damage of veins and complicated course caused by the weakness of the connective-tissular carcass of a vein wall as well as by evident disorders of flow and coagulation properties of blood. Patients with varicose disease secondary to the evident (expressed) connective tissue dysplasia are in the risk group of palindromia, thrombus complications and trophesies development, need dispensary observation for proper treatment in good time.