Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice

Dosso Mamadou, Coulibaly Adama, Coulibaly Ousmane, Soro Doudjo, N'guessan J. David
2020 International Journal of Pharmacology and Toxicology  
This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p <0.01-0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the
more » ... nduced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p < 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation.
doi:10.14419/ijpt.v8i1.30635 fatcat:onshpgfkwjgyfk7hzjtwukenri