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Can the Smudge Cells Be Counted As Lymphocytes in the Differential Leukocyte Counts Performed on Peripheral Blood Smears of Chronic Lymphocytic Leukemia Patients?
American Journal of Clinical Pathology
Objectives: Two characteristic peripheral blood smear findings of patients with chronic lymphocytic leukemia (CLL) are lymphocytosis and many smudge cells. Excluding smudge cells from manual differential (MDIFF), a common laboratory practice, yields unreliable results and consequently necessitates MDIFF on an albumenized blood smear. Since smudge cells represent remnants of fragile lymphoid cells, we sought to (1) test the hypothesis that reliable MDIFF results can be obtained from thedoi:10.1093/ajcp/aqw151.021 fatcat:of7wvlopvfbp5pz7263aum6hja