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N-Myc Inhibition: Advances in Neuroblastoma Treatment
2017
CellBio
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Neuroblastoma (NBL) is one of the most common solid tumors and around 15% of cancer mortality in children. Amplification of the N-Myc proto-oncogene is strongly correlated with advanced disease and poor clinical outcome in NBL. Recent studies described that ubiquitin-specific protease 7 (USP7; also known as HAUSP) interacts with N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that in-turn potentiates N-Myc function, and treatment with the HAUSP inhibitor (P22077) blocked
doi:10.4236/cellbio.2017.63003
fatcat:fq5gizrwvnhj7blu3chfk7av7a