Analgesic Activity Of Vigna Unguiculata In Cd-1 Mice Following Formalin Administration

Aduema W, U Azunna, J.U Agbai
2017 Zenodo  
This study was intended to determine the effects of Vigna unguiculata on pain sensation in 40 adult Swiss white mice. The mice were randomly selected into four groups (A, B, C and D) and allowed to acclimatize for a period of 3 weeks. With free access to food and water. They were subsequently subjected to a treated period of 4 weeks, during which group B,C and D(test group)received cooked, uncooked beans and serotonin precursor diets containing 50%(cooked and uncooked beans) and
more » ... and 0.2/50g)serotonin precursor diets. Group A, however (control), received normal rodent chow. The results in the formalin test, shows that the frequency and duration of paw attention in both phases of the test groups was significantly lower (P< 0.05) compared to the control group. The duration and frequency of paw licks (P<0.05) was also significantly lower in the beans diet and serotonin precursor group compared to the control. Therefore, chronic consumption of Vigna unguiculata diet may decrease pain sensation.
doi:10.5281/zenodo.838306 fatcat:ut5zuucylrbpxn6wuycefpu56e