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Scholars Research Library Der Pharma Chemica
A new HPLC method was developed for selective and simultaneous determination of Guaifensen and Dextromethorphan HBr tablets 1200/60 mg. The chromatographic separation was achieved on a Acquity UPLC BEH, C18,100 x 2.1 mm, 1.7um column. The mobile phase consisted of buffer, acetonitrile and methanol delivered at a flow rate of 0.15 ml/min and dual wavelength at 271 nm for Guaifensin and 220 nm for Dextromethorphan with UV detector. Accuracy found by % recovery from 98.2 to 102.2 at 50 to 150%fatcat:ascgvww3inbcff7q2t3wz4r6im