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Recent Advances in Asthma Research and Treatments
It is well established that allergic asthma is T cell-driven disease where CD4+ T cells of Th2 phenotype play a critical role in disease initiation and maintenance. There are several critical steps in the induction of Th2 type immune response to the allergen. The first critical step is the antigen processing and presentation of allergen-derived peptides in the context of specific major histocompatibility Class II (MHCII) molecules by antigen-presenting cells (APC). Recognition of this complexdoi:10.5772/intechopen.102631 fatcat:4jxtf46fdvhufo2uofpvq2zbyi