A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

Heike Kollmus, Mouse Phenome Database Team, Helmut Fuchs, Christoph Lengger, Hamed Haselimashhadi, Molly A. Bogue, Manuela A. Östereicher, Marion Horsch, Thure Adler, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker (+29 others)
2020 Mammalian Genome  
The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy
more » ... bolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.
doi:10.1007/s00335-020-09827-3 pmid:32060626 fatcat:hnzirj4irrca3gzfip346ycb7y