Synthesis of 3-Ethanoyl/Aroylacetylindoles in Water

Xiaoyu Hu, Haifeng Yu, Wenju Wang, Siao Jiang, Qi Liu, Jie He
2019 Youji huaxue  
4-Dodecylbenzenesulfonic acid (DBSA) catalyzed hydrolysis reaction of β-ethylthio-β-indolyl-α,β-unsaturated ketones (1) in water to yield 3-ethanoyl/aroylacetylindoles (2) was studied. It showed that the hydrolysis of 1 in water smoothly occurred in the presence of 10 mol% DBSA in reflux water, and 2 was obtained in excellent yield.
doi:10.6023/cjoc201904002 fatcat:dsf6yvsfhvczllg7otrg3gcnoi