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Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative
2007
Chemical and pharmaceutical bulletin
Preserved Fulltext
Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20 h at r.t., followed by pseudomerization in ice-water, gave a d d 20(22) -pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing activities.
doi:10.1248/cpb.55.1077
pmid:17603206
fatcat:2avdfx2ltzdrbik6svta4q7ya4