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Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells
2006
Oncology Reports
The Hedgehog (Hh) signaling pathway and the Wnt signaling pathway are known to play important roles in carcinogenesis and the progression of various human malignant tumors. Although a relationship between these two pathways has recently been reported, the mechanism by which ß-catenin, one of the key molecules of the Wnt signaling pathway, influences the Hh pathway has not yet been revealed in detail. To clarify the role of ß-catenin in relation to the Hh signaling pathway, we transfected GLI1
doi:10.3892/or.16.1.91
fatcat:ibhszvmgbzh6dlbec24eemg7je