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NECAP2 controls clathrin coat recruitment to early endosomes for fast endocytic recycling
Journal of Cell Science
Endocytic recycling returns receptors to the plasma membrane following internalization and is essential to maintain receptor levels on the cell surface, resensitize cells to extracellular ligands and for continued nutrient uptake. Yet, the protein machineries and mechanisms driving endocytic recycling remain ill-defined. Here, we establish that NECAP2 regulates the endocytic recycling of EGFR and transferrin receptor. Our analysis of the recycling dynamics revealed that NECAP2 functions in thedoi:10.1242/jcs.173708 pmid:27206861 fatcat:vl6pskovrrbbniqdnqjxpty5fm