Age-Related Neural Dedifferentiation and Cognition [post]

Joshua Koen, Sabina Srokova, Michael Rugg
2019 unpublished
This review focuses on possible contributions of neural dedifferentiation to age-related cognitive decline. Neural dedifferentiation is held to reflect a breakdown in the functional specificity of brain regions and networks. The evidence for age-related dedifferentiation is robust when it is operationalized as neural selectivity for different categories of perceptual stimuli or as decreased segregation or modularity of resting-state functional brain networks. Neural dedifferentiation for
more » ... ual categories appears to demonstrate a negative, age-invariant relationship with cognitive performance. Whether this pattern extends to network-level measures of dedifferentiation cannot currently be determined due to insufficient evidence. The existing data highlight the importance of further examination of neural dedifferentiation as a factor contributing to cognitive aging and to cognitive performance more generally.
doi:10.31219/ fatcat:kgzydz4j5bdnxpwv43nzm4pfam