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Losartan reduces sympathetic nerve outflow from the brain of rats with chronic renal failure
Journal of the Renin-Angiotensin-Aldosterone System
Sympathetic nervous system (SNS) activity, measured by norepinephrine (NE) turnover rate, was greater in the posterior hypothalamic (PH) nuclei, the paraventricular nuclei (PVN), and the locus coeruleus (LC) of 5/6 nephrectomised (CRF) rats than of control rats. NE secretion from the PH was also greater in CRF than in control rats. These findings demonstrate that SNS activity plays an important role in the genesis of hypertension associated with CRF. The increase in central SNS activity wasdoi:10.3317/jraas.2000.026 pmid:11967814 fatcat:7ie5k5raezb47lux6v6xz7kqwa