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Bosentan in Pediatric Patients with Pulmonary Arterial Hypertension
Current Vascular Pharmacology
OBJECTIVE: In order to provide an overview of current knowledge, the literature was systematically examined for clinical studies, which evaluate the safety and effectiveness of bosentan in pediatric pulmonary arterial hypertension (PAH). SOURCES: 3 databases (MEDLINE, EMBASE and BIOSIS) were searched for the period January 2000 -October 2007 using the key words 'pulmonary arterial hypertension', 'bosentan', and 'pediatric patients/children'. RESULTS: Of 165 identified publications, 21 clinicaldoi:10.2174/157016109787455653 pmid:19356006 fatcat:hwptywpx7bd7nefjkrtxi3lnh4