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Enhancement of Vincristine Cytotoxicity in Drug-Resistant Cells by Simultaneous Treatment With Onconase, an Antitumor Ribonuclease
Journal of the National Cancer Institute
Onconase, a protein isolated from oocytes and early embryos of the frog Rana pipiens, shares extensive homology with bovine pancreatic ribonuclease (RNase A) and possesses similar enzyme activity. Onconase is cytotoxic toward cancer cells in vitro and exhibits antitumor activity in animal models. In addition, Onconase has been shown to enhance the cytotoxic activity of some chemotherapeutic agents in vitro. Purpose: We studied interactions between the cytotoxic effects of Onconase and thedoi:10.1093/jnci/88.11.747 pmid:8637029 fatcat:lmlxnroggfhrxetrygd6t2mpnq