Uterine fibroids and fertility: a modern view of the problem. A literature review

Vitaly Bezhenar, Viktor A. Linde, Biuzand V. Arakelyan, Elmina E. Sadykhova, Maria V. Reznik, Viktoria A. Tarasenkova
2022 Journal of obstetrics and women s diseases  
The review was made based on https://cyberleninka.ru/, PubMed, MedArt and https://rucml.ru/. Uterine fibroid is one of the most common noninflammatory diseases of female reproductive system of reproductive age. Estrogens and progesterone are tightly connected with various growth factors such as transforming growth factor beta, insulinlike growth factor, endothelial growth factor etc. Dysfunction of sex steroids, alteration of myometrium vascularization and proinflammatory changes of
more » ... associated with leiomyoma can prevent from adequate preparation of endometrium to implantation. The situation is often complicated by combination of leiomyoma and adenomyosis. Pregnancy in women with leiomyoma is associated with increased risk of miscarriage, preeclampsia and placental insufficiency. Isthmic localization of uterine fibroid is considered to be the most unfavorable as it increases the risk of cervical insufficiency. Thus, uterine fibroid is a serious reproductive problem associated with fertility reduction and other problems with childbearing.
doi:10.17816/jowd78831 fatcat:q6qzzbcyuffcjaxz63rtraqaee