Evaluation of Mesenchymal Stem Cells and Granulocyte Colony Stimulating Factor in Treatment of Complete Spinal Cord Injury

2018 Journal of Experimental and Clinical Neurosciences  
Objective: Spinal cord injury (SCI) mostly affects the young and has no definite treatment. There is a growing body of literature showing the efficacy of stem cells or growth factors in the treatment of partial SCI, but a few studies demonstrated complete SCI recovery. Thus, the aim of the present study was to assess the efficacy of Mesenchymal Stem Cells (MSCs) or Granulocyte Colony Stimulating Factor (GCSF) therapy in the complete SCI recovery. Material and Methods: 45 Rats were divided into
more » ... groups (GCSF, MSCs, GCSF + MSCs, control, and sham) and underwent SCI (except the sham group) using aneurysmal clip compression. Each group received its relevant therapy. Results: After induction of SCI, there was a non-significant increasing trend in (Louisville Swim Scale) (LSS) score in all the treated groups, notwithstanding a plateau in the recovery in the sham group. No significant difference was found in the locomotor recovery among the groups. Conclusion: The evidence from the present study indicates that GCSF and MSCs therapy fail to recover SCI.
doi:10.13183/jecns.v5i1.77 fatcat:w56t5cqgczf5ndl43s7hxehfbm