CanvasXpress was developed as the core visualization component for bioinformatics and systems biology analysis at Bristol-Myers Squibb and further enhanced by scientists around the world and served as key visualization engine for many popular bioinformatics tools. It supports a large number of visualizations as shown at http://canvasxpress.org to display mainly scientific and genomics data that includes sophisticated plots such as oncoprint of cancer mutations, heatmap, 3D scatter, violin,

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... r, and profile plot as illustrated in Figure 1 that is arranged together by the accompanying html based tool, canvasDesigner (https://baohongz.github.io/canvasDesigner). Recently, reproducibility and usability of the package in real world bioinformatics and clinical use cases have been improved significantly witnessed by continuous add-on features and wide adoption of the toolkit in the scientific communities. Furthermore, It is the first noteworthy package harmonizing real time interactive exploration and analysis of big data, full-fledged customization of look-n-feel, and production of multi-panel publication-ready figures in PDF format simultaneously.