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A-Star, an Argonaute-directed System for Rare SNV Enrichment and Detection
[article]
2019
bioRxiv
pre-print
The detection of rare polymorphic alleles, especially single nucleotide variations (SNVs), is becoming increasingly relevant for the early diagnosis and monitoring of a variety of tumors. However, the broad clinical applicability of SNV detection has been limited by the low sensitivity, flexible target selection andmultiplexing offered by existing SNV detection methods. Here, we developed a simple but efficient single-tube PCR system, referred to as A-Star (Ago-directed specific target
doi:10.1101/803841
fatcat:txdej5k2ebfc7nisxwrihindmu