Efficacy of Enamel Matrix Proteins in Periodontal Regeneration of Intraosseous Defects: An Umbrella Review

Rubiel Marín Jaramillo, Sebastian Frías Tarón
2020 Oral Health & Dental Science  
Periodontitis is a chronic inflammatory disease that affects the supporting tissues of the teeth. When periodontal disease progress, it is common to find intrabony defects, one of the alternatives for its treatment is the use of enamel-matrix derivative proteins. The present umbrella review aimed to assess the effectiveness of enamel-matrix derivative proteins in periodontal regenerative treatment of intrabony defects. A review of systematic reviews published between January 2000 and March 2019
more » ... 2000 and March 2019 in indexed journals was performed. The qualitative evaluation was conducted using the AMSTAR-2 guide. Data analysis was purely qualitative. Nine (9) systematic reviews with meta-analysis were selected. An average reduction in PPD of 4,10mm and an average increase of 3,32mm in CAL were observed, showing statistically significant differences supporting the intervention with EMD in comparison with open flap debridement (OFD). Differences found between the included articles were statistically significant, showing better outcomes for the treatment with EMD combined with periodontal therapy. However, these results should be carefully interpreted because of the methodological variability between studies.
doi:10.33425/2639-9490.1062 fatcat:yniosqwwnbg45grqlsf7mcibna