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Periodontitis is a chronic inflammatory disease that affects the supporting tissues of the teeth. When periodontal disease progress, it is common to find intrabony defects, one of the alternatives for its treatment is the use of enamel-matrix derivative proteins. The present umbrella review aimed to assess the effectiveness of enamel-matrix derivative proteins in periodontal regenerative treatment of intrabony defects. A review of systematic reviews published between January 2000 and March 2019doi:10.33425/2639-9490.1062 fatcat:yniosqwwnbg45grqlsf7mcibna