SIMULTANEOUS DETERMINATION OF KETOPROFEN AND METHYL PARABEN, PROPYL PARABEN IN BULK AND FORMULATED GEL BY SPECTROPHOTOMETRY
Journal of Pharmaceutical and Scientific Innovation
UV Derivative Spectrophotometric methods for Method I simultaneous determination Method II the first derivative method of Ketoprofen, Methyl Paraben and Propyl Paraben, in Gel was developed in the present work. Spectrophotometric methods for simultaneous determination and the first derivative method of Ketoprofen, Methyl Paraben and Propyl Paraben at 288 nm, 308 nm and 309 nm for KETO, MP and PP respectively. The various parameters were studied according to (ICH). The linearity lies between
... ty lies between 10-50 ug/ml for Ketoprofen and 2-10 ug/ml for Methyl Paraben (MP), 0.2-1.0 ug/ml for Propyl Paraben, (PP) for all the two methods. Method II the first derivative method was measured at 306.5 nm, 312.5 nm and 318 nm being Zero crossing point for KETO, MP and PP respectively in Methanol and distilled water (50:50). The proposed method has estimated for method I KETO 100.04 ± 0.372 and MP 99.44 ± 0.112, PP 99.17 ± 0.051 and for Method II KETO 101.17 ± 0.523 and 99.75 ± 0.251, PP 98.17 ± 0.126 in Formulated Gel All the methods showed good reproducibility and recovery with % RSD less than 1.