Integrated Transcriptomic and Metabolomic Analysis of Lymantria dispar multiple nucleopolyhedrovirus (LdMNPV) infected Lymantria dispar in Tree-top Disease [post]

Fengjiao Li, Yajie Wang, Xiao Yu, Dun Wang
2021 unpublished
The pioneer record described the phenomenon of nucleopolyhedroviruses (NPVs) manipulating host behavior was named as Tree Top Disease or "Wipfelkrankheit" by Hofmann in 1891. Following publics advised multipartite effect during infection progressing that NPVs adjusting manipulated mode to actualize crossing barriers, immune escape and hormone regulation. In this study, the molecular mechanism of Lymantria dispar Multiple embedded Nucleopolyhedrovirus(LdMNPV)-infected was investigated by a
more » ... stigated by a comparison of transcriptomic and metabolomic analysis at four selected time points of LdMNPV-infected and healthy Lymantria dispar (Ld) larvae. Among data collecting, the notably up-regulated and down-regulated genes and metabolomics were used for further analysis. Integrative analysis revealed the content changes of caffeine, glutamate and gamma-Aminobutyric acid involved in LdMNPV inducing behavior change, and the alteration of myo-inositol, phosphatidyl-1D-myo-inositol and relevant genes involved in larval extended instar duration and apoptosis avoiding.
doi:10.21203/rs.3.rs-414994/v1 fatcat:brha62vfwfexzc33qmori7eiga