Accurate cardiac computing, analysis and modeling from multi-modality images are important for the diagnosis and treatment of cardiac disease. Late gadolinium enhancement magnetic resonance imaging (LGE MRI) is a promising technique to visualize and quantify myocardial infarction (MI) and atrial scars. Automating quantification of MI and atrial scars can be challenging due to the low image quality and complex enhancement patterns of LGE MRI. Moreover, compared with the other sequences LGE MRIs

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... ith gold standard labels are particularly limited, which represents another obstacle for developing novel algorithms for automatic segmentation and quantification of LGE MRIs. This chapter aims to summarize the state-of-the-art and our recent advanced contributions on deep learning based multi-modality cardiac image analysis. Firstly, we introduce two benchmark works for multi-sequence cardiac MRI based myocardial and pathology segmentation. Secondly, two novel frameworks for left atrial scar segmentation and quantification from LGE MRI were presented. Thirdly, we present three unsupervised domain adaptation techniques for cross-modality cardiac image segmentation.