Systematic Analysis Reveals that Cancer Mutations Converge on Deregulated Metabolism of Arachidonate and Xenobiotics

Francesco Gatto, Almut Schulze, Jens Nielsen
2016 Cell Reports  
Graphical Abstract Highlights d Cancer-type independent correlations exist between mutated genes and gene expression d Nine of 158 mutated genes correlated with expression changes, chiefly in metabolism d These changes converged on a sub-network centered on arachidonate and xenobiotics d The correlations were validated in 4,462 independent samples
doi:10.1016/j.celrep.2016.06.038 pmid:27396332 fatcat:l4yn4zjaerfvdpmmgfgyqhdyva