Synthesis of 2-amino- and 2-arylazoazulenes via nucleophilic aromatic substitution of 2-chloroazulenes with amines and arylhydrazines

Taku Shoji, Shuhei Sugiyama, Takanori Araki, Akira Ohta, Ryuta Sekiguchi, Shunji Ito, Shigeki Mori, Tetsuo Okujima, Masafumi Yasunami
2017 Organic and biomolecular chemistry  
The SNAr reaction of 2-chloroazulene derivative 1 with ethoxycarbonyl groups at the 1,3-positions of the azulene ring with several amines afforded the corresponding 2-aminoazulenes 3–9 in excellent yields.
doi:10.1039/c7ob00691h pmid:28426084 fatcat:qiqgvcwo5fh4hna2n56lomjko4