A systematic review is intended to combine outcome data from published studies in a population. It is based on a number of steps and there are numerous advantages in conducting systematic reviews which dentists have been finding difficulties in performing them. These reviews are a key element of evidencebased health care, yet they remain in some ways mysterious. A review earns the adjective systematic if it is based on a clearly formulated question, identifies relevant studies, appraises their

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... uality, and summarizes the evidence by use of definitive methodology. Taken into account the misconceptions and complications in conducting these kinds of studies, this article aims to guide readers for understanding, performing, and interpreting comprehensive systematic reviews in dental research.