For decades there has been discussion whether thyroid disorders could cause gall stone disease. There could be several explanations for possible relation between hypothyroidism and gall stone disease. Objective: To know the association of thyroid functions tests in diagnosed cases of gall stone disease. Setting: It is a prospective study. 200 patients with biliary calculi were included in the study. Result: 143(71.5%) were females and 57(28.5%) were males with median age was 40 yrs. Thyroid

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... rder in form of hypothyroidism was found in 37(18.5%) patients (high TSH levels than normal value for their age), 28(19.6%) were females and 9(15.8%) males. Among 37 hypothyroidism cases 21(10.5%) are subclinical hypothyroidism and 16(8%) were clinical hypothyroidism. Clinically 37 out of 200 patients high level of TSH is statistically not significant (p= 0.849). However low levels of T3 levels associated with high TSH in clinical hypothyroidism is statistically significant (p=0.047). Conclusion: It was concluded in our study there was high TSH levels in patients with biliary calculi but it's not statistically significant however low T3 with high TSH has statistically significant.