Synovial sarcoma of the extremities and trunk: a long-lasting disease

A. Gofman, J. Issakov, Y. Kollender, V. Soyfer, S. Dadia, I. Jiveliouk, G. Flusser, J. Bickels, I. Meller, O. Merimsky
2007 Oncology Reports  
Synovial sarcoma (SS) of an extremity or trunk is relatively rare and is approached by limb sparing surgery (LSS), radiation therapy (RT) and chemotherapy. We conducted a retrospective analysis of the clinical and histopathological data of 73 patients with proven SS. At a median follow-up time of 6 years, local recurrence was seen in 17.8 and systemic recurrence 35.6% of patients (local-only, 6.8; systemic-only, 24.6; combined, 11%). The 10-year local recurrence-free survival (LRFS), systemic
more » ... (LRFS), systemic recurrence-free survival (SRFS) and overall survival (OS) rates were 78, 68 and 61%, respectively. LRFS was significantly better in patients treated with isolated limb perfusion (ILP); SRFS was influenced by the delay until diagnosis. The practical aspects of our observations are the need for long-term follow-up in order to diagnose recurrences, the fact that not all local or distant recurrences are necessarily associated with a shortening of OS time and the important role of induction ILP with TNF in cases of extremity SS.
doi:10.3892/or.18.6.1577 fatcat:3hdpsll4tnbxff464u7l4vtwlu