No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation

Seongsoo Hwang, Yi-Deun Jung, Kahee Cho, Sun-A Ock, Keon-Bong Oh, Heui-Soo Kim, Ik-Jin Yun, Curie Ahn, Jin-Ki Park, Seoki Im
2014 Laboratory Animal Research  
This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organrecipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from α-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted
more » ... GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
doi:10.5625/lar.2014.30.2.90 pmid:24999364 pmcid:PMC4079837 fatcat:hnrwzzqojvb5vojra7lav4jneq