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Oocyte and cumulus cell cooperativity and metabolic plasticity under the direction of oocyte paracrine factors
Mammalian oocytes develop and mature in a mutually dependent relationship with surrounding cumulus cells. The oocyte actively regulates cumulus cell differentiation and function by secreting soluble paracrine oocyte-secreted factors (OSFs). We characterized the molecular mechanisms by which two model OSFs, cumulin and BMP15, regulate oocyte maturation and cumulus-oocyte cooperativity. Exposure to these OSFs during maturation altered the proteomic and multispectral autofluorescence profiles ofdoi:10.1101/2022.09.05.506599 fatcat:w6fwng67zbgqbc723qax6q3qxy