Card-placing test in amnestic mild cognitive impairment and its neural correlates

Seong-Joon Lee, Young-Sil An, Tae Sung Lim, So Young Moon
2014 BMC Neurology  
Backgroud: We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). Methods: Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the
more » ... T with adjustment of age, education and sex of patients. Results: The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus. Conclusions: This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI.
doi:10.1186/1471-2377-14-123 pmid:24906452 pmcid:PMC4058449 fatcat:2mizoaxswbd2pc3yjbh5issgdu