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Cancer Drug Resistance
The type 2 DNA topoisomerases (Top2) are conserved enzymes and biomarkers for cell proliferation. The catalytic activities of the human isoform Top2a are essential for the regulation of DNA topology during DNA replication, transcription, and chromosome segregation. Top2a is a prominent target for anti-cancer drugs and is highly regulated by post-translational modifications (PTM). Despite an increasing number of proteomic studies, the extent of PTM in cancer cells and its importance in drugdoi:10.20517/cdr.2019.114 fatcat:mtmxby3dqnfylkctggewn42fky