Transforaminal intrathecal administration of nusinersen for patient with spinal muscular atrophy: report of two cases with severe spinal deformity
脊髄性筋萎縮症患者に対する脊髄くも膜下穿刺時に経椎間孔アプローチが有用であった2症例

Ayako HYOUDOU, Shinichi YAMADA, Sayo NAKAO, Katsuya TSUDA, Taishi YOKOMIZO, Teruyuki HIRAKI
Journal of Japan Society of Pain Clinicians  
Spinal muscular atrophy (SMA) is a genetic disease characterized by degeneration of the spinal cord, resulting in progressive muscle atrophy. Recently, nusinersen has been approved for treating SMA, which should be administered intrathecally. However, lumbar puncture is often technically challenging in patients with SMA because of young age, spinal deformity, scoliosis, and abnormal spinal rotation. Patient 1 was a 36-year-old woman with SMA type 2. Patients 2 was a 17-year-old girl with SMA
more » ... e 1. We report two patients with SMA in whom intrathecal administration of nusinersen can be achieved safely using a transforaminal approach.
doi:10.11321/jjspc.20-0038 fatcat:327vmu75g5aaldtbqfkftcegee