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Nuclear Factor-κB Directs Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 Receptor Expression inNeisseria gonorrhoeae-infected Epithelial Cells
Journal of Biological Chemistry
The human-specific pathogen Neisseria gonorrhoeae expresses opacity-associated (Opa) protein adhesins that bind to various members of the carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family. In this study, we have analyzed the mechanism underlying N. gonorrhoeae-induced CEACAM up-regulation in epithelial cells. Epithelial cells represent the first barrier for the microbial pathogen. We therefore char- (NF-B) , which translocates as a p50/p65 heterodimer into the nucleus,doi:10.1074/jbc.m108135200 pmid:11751883 fatcat:jurifayxb5hatiblnj2fcvb2xi