Antiphospholipid antibody syndrome with thrombotic splenic infarcts associated with acute cytomegalovirus infection

Christopher Denham, Ginger Tissier, Amit Golding
2019 Access Microbiology  
We describe a case of acute cytomegalovirus (CMV) infection complicated by acquired antiphospholipid antibodies and splenic thrombi. We discuss the associations between CMV infection and thrombosis risk and correlation with antiphospolipid antibodies. A previously healthy 32-year-old woman is hospitalized for acute abdominal pain and fever and found to have multiple splenic infarcts on an abdominal computed tomography (CT) scan. An infectious work-up is negative except for acute CMV, and a
more » ... coagulable work-up is only positive for antiphospholipid antibodies. The patient is discharged and placed on anti-coagulation therapy for 6 months. Co-incident thrombosis and antiphospholipid antibody syndrome can occur with acute viral infections, including CMV. We discuss the viral infection-associated increased risk of developing blood clots and antiphospholipid antibodies as being either correlative with or causative of viral-induced thrombosis.
doi:10.1099/acmi.0.000032 pmid:32974541 pmcid:PMC7481732 fatcat:ux6ehqluljdrfpd5uzdozs4yqi