A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

Aeysha Sultan, Mian Habib Ur Rehman, Noreen Sajjad, Ali Irfan, Irfan Ullah, Muhammad Mustaqeem, Muhammad Saleem, Syeda Laila Rubab, Muhammad Rafiq, Muhammad Khalid, Katarzyna Kotwica-Mojzych, Mariusz Mojzych (+1 others)
2020 PLoS ONE  
A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against
more » ... tive (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.
doi:10.1371/journal.pone.0229891 pmid:32497076 fatcat:j6oxb7ud3jewve6tdlo7gtye3i