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Methanolic extracts from roots and cell suspension cultures of Waltheria americana Linn induce GABA release in cerebral slices of mouse brain
African Journal of Pharmacy and Pharmacology
This study evaluates and compares the release of the neurotransmitter γ-aminobutyric acid (GABA) induced by methanolic extracts obtained from roots of wild plants and from cell suspension cultures of W. americana Linn. The release of this neurotransmitter was evoked by crude and fractioned extracts derived from both roots of wild plant and cell suspension cultures, tested at three concentrations: 10, 50 and 100 µg/ml by means of in vitro incubation of slices of mouse cerebral cortex. Firstly,doi:10.5897/ajpp2014.4115 fatcat:m2awb7sjuvciljykxfxjvlsvku