A human cardiopulmonary system model applied to the analysis of the Valsalva maneuver

K. Lu, J. W. Clark, F. H. Ghorbel, D. L. Ware, A. Bidani
2001 American Journal of Physiology. Heart and Circulatory Physiology  
A human cardiopulmonary system model applied to the analysis of the Valsalva maneuver. Am J Physiol Heart Circ Physiol 281: H2661-H2679, 2001.-Previous models combining the human cardiovascular and pulmonary systems have not addressed their strong dynamic interaction. They are primarily cardiovascular or pulmonary in their orientation and do not permit a full exploration of how the combined cardiopulmonary system responds to large amplitude forcing (e.g., by the Valsalva maneuver). To address
more » ... uver). To address this issue, we developed a new model that represents the important components of the cardiopulmonary system and their coupled interaction. Included in the model are descriptions of atrial and ventricular mechanics, hemodynamics of the systemic and pulmonic circulations, baroreflex control of arterial pressure, airway and lung mechanics, and gas transport at the alveolar-capillary membrane. Parameters of this combined model were adjusted to fit nominal data, yielding accurate and realistic pressure, volume, and flow waveforms. With the same set of parameters, the nominal model predicted the hemodynamic responses to the markedly increased intrathoracic (pleural) pressures during the Valsalva maneuver. In summary, this model accurately represents the cardiopulmonary system and can explain how the heart, lung, and autonomic tone interact during the Valsalva maneuver. It is likely that with further refinement it could describe various physiological states and help investigators to better understand the biophysics of cardiopulmonary disease. cardiopulmonary modeling; ventricular interaction; closedloop hemodynamics; baroreflex control; airway mechanics; gas exchange THE DIAGNOSIS AND TREATMENT of cardiopulmonary disease may be improved by using mathematical models of the cardiovascular and pulmonary systems. With this in mind, we developed a model of the cardiopulmonary system of the normal human subject that not only represents the system accurately but also predicts its response to a variety of commonly used diagnostic procedures. To our knowledge, this is the first example of a truly integrative model of the cardiopulmonary system. Recently, our group (5, 25) developed a multicompartment model of the canine circulation. We have now modified and extended this cardiovascular model to
doi:10.1152/ajpheart.2001.281.6.h2661 pmid:11709436 fatcat:sx6aqpdwzfhy5p2yi4n7gyrbq4