BIOCHEMICAL CHANGES IN MITOCHONDRIA AND ITS ROLE IN CELL DEATH DURING MYOCARDIAL ISCHEMIA-REPERFUSION INJURY

Livan Delgado Roche, Nielsen Denis, Gregorio Martínez Sánchez
unpublished
Myocardial ischemia-reperfusion injury is a major contributor to the mortality associated with coronary artery disease. Although mitochondria maintain normal heart function by providing virtually all of the heart´s ATP, is also implicated in the development of ischemic damage. While ischemic injury has long been considered to result in necrotic tissue damage, studies over the past decade have focused attention on apoptosis as a significant component of cell loss following myocardial infarction.
more » ... cardial infarction. Also a substantial body of evidence implicates reactive oxygen species and oxidative stress in the cellular injury induced by ischemia-reperfusion in the heart. Cell damage can occur through mechanism involving lipid peroxidation, covalent modification of protein and mitochondrial DNA oxidation. Reactive oxygen species contributes to irreversible damage of mitochondrial function and consequent, impaired recovery of physiological function and cell death.
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