Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

Marco Antonio dos Anjos Corvo, Claudia Alessandra Eckley, Luis Vicente Rizzo, Luiz Roberto Sardinha, Tomas Navarro Rodriguez, Ivo Bussoloti Filho
2014 Brazilian Journal of Otorhinolaryngology  
Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming growth factor alpha levels were observed in dyspeptic patients, but there have been no studies in patients with Sjögren's syndrome and laryngopharyngeal reflux. Objective: To compare the salivary transforming growth
more » ... ansforming growth factor alpha levels of patients with Sjögren's syndrome and laryngopharyngeal reflux to those of healthy controls. Methods: This is a prospective controlled study. Twelve patients with Sjögren's syndrome and laryngopharyngeal reflux and 11 controls were prospectively evaluated. Spontaneous and stimulated saliva samples were obtained to establish salivary transforming growth factor alpha concentrations. Results: The salivary transforming growth factor alpha levels of patients were significantly higher than those of healthy controls. Five patients with laryngopharyngeal reflux also had erosive esophagitis; their salivary transforming growth factor alpha levels were comparable to controls. ଝ Please cite this article as: Corvo MA, Eckley CA, Rizzo LV, Sardinha LR, Rodriguez TN, Bussoloti Filho I. Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis. Braz J Otorhinolaryngol. 2014;80:462---9.
doi:10.1016/j.bjorl.2014.08.006 pmid:25457064 fatcat:5bs6xbyyzvcobippzindzifhem