Expression of VEGF-C and its association with clinicopathological features among patients with gastric cancer undergoing gastric surgery at Tongji medical hospital, China
Objectives: Gastric cancer shows epidemiological variability according to geographic locations. These differences have been demonstrated both regionally and within countries. Currently, there is no baseline protocol regarding using VEGF-C as a tumor marker in a local setting, therefore, it was necessary to conduct a study to analyze the correlation between VEGF- C and clinicopathological parameters in patients with gastric cancer undergoing a surgical procedure at Tongji medical
... cal hospital.Results: 161 samples were analyzed from Chinese patients who had undergone either palliative or curative surgical procedure between October 2015 and September 2017 at Tongji medical hospital. Immunohistochemistry was used to analyses presence of VEGF-C in tissues. Among the 161 samples from gastric cancer patients, 101 (62.7%) samples showed strong VEGF-C expression and 60 (37.3%) samples showed weak VEGF-C expression. Multivariate logistic regression analysis was used to show statistical significance with strong expression of VEGF-C for tumor grade, invasion of lymph nodes and TNM staging. Strong expression of VEGF-C was significantly more likely in adenocarcinoma of gastric cancer. VEGF-C may be used as a biological marker for assessing the biological characteristics of gastric cancer.