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The sirtuins are a family of nicotinamide adenine dinucleotide (NAD þ )-dependent protein deacetylases that regulate cell survival, metabolism, and longevity. Humans have seven sirtuins (SIRT1-SIRT7) with distinct subcellular locations and functions. SIRT3 is localized to the mitochondrial matrix and its expression is selectively activated during fasting and calorie restriction. Activated SIRT3 deacetylates several key metabolic enzymes-acetyl-coenzyme A synthetase, long-chain acylcoenzyme Adoi:10.1101/sqb.2011.76.010850 pmid:22114326 fatcat:s4iwjvtdlfbzhhcjliopzlaati