SUPPRESSION OF URINARY AND PLASMA FOLLICLE STIMULATING HORMONE BY EXOGENOUS ESTROGENS IN PREPUBERTAL AND PUBERTAL CHILDREN

R. P. KELCH, S. L. KAPLAN, M. M. GRUMBACH
1973 Obstetrical and Gynecological Survey  
Clomiphene citrate, an "anti-estrogen" with mild estrogenic properties, inhibits rather than stimulates gonadotropin excretion in prepubertal and early pubertal children. These and other data suggest that the sensitivity of the hypothalamic-pituitary "gonadostat" decreases at the onset of puberty. To test this hypothesis further, the daily excretion of urinary folliclestimulating hormone (FSH) and luteinizing hormone (LH) was determined in 19 children (5 "short normals" and 14 with isolated
more » ... 4 with isolated human growth hormone (HGH) deficiency) who were given ethinyl estradiol (EE) 1.4-14.7 µg/m 2 per day (2-10 µg/day) for 4 to 7 days. In addition, plasma and urinary gonadotropins and plasma estrogens were serially determined in two prepubertal females(with isolated HGH deficiency) given two injections (24 h apart) of estradiol benzoate, 10 µg/kg. FSH and LH concentrations in plasma and kaolin-acetone urinary concentrates and plasma 17b-estradiol (E 2 ) and estrone (E 1 ) were measured by radioimmunoassays. 2-3 µg/m 2 per day of EE significantly suppressed urinary FSH (and LH when detected in the control period) in two out of six prepubertal children, while all doses >5 µg/m 2 per day suppressed urinary gonadotropins to undetectable levels in eight prepubertal subjects. In early to midpubertal subjects. 2-10 µg/m 2 per day of EE produced a slight suppression of urinary FSH, but failed to suppress to undetectable levels. Two subjects in late puberty (stage 4) did not suppress their urinary FSH [...]
doi:10.1097/00006254-197311000-00017 fatcat:uo3s7mos65apfhwu5oqzxartum