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Structure and Dynamics of the Receptor:Kinase Complex that Mediates Bacterial Chemotaxis
2015
Biophysical Journal
CheA and CheW, peptides exhibit protection from exchange at long times (16 hours) that is greater in the kinase-on state. HDX-MS of complexes prepared using different means of shifting the signaling state will reveal which changes correlate with kinase activity and will quantify stabilization of receptor subdomains and binding interfaces that contribute to receptor control of kinase activity. Thus HDX-MS provides an important tool in a hybrid approach for understanding structure and mechanism
doi:10.1016/j.bpj.2014.11.258
fatcat:qwvq2q6zvbh4xmpwc2xre72o44