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Physical activity can reduce sympathetic tone and may be beneficial to human health. Whether the vascular responses to norepinephrine (NE), an adrenergic vasoconstrictor, could be altered by chronic exercise was unclear. We therefore conducted this study to investigate the effects of endurance exercise training on NE-induced vasoconstrictive response in healthy rabbits. Possible mechanisms were also studied. Methods and Results Twenty-four male New Zealand White rabbits were used for thisdoi:10.1161/01.cir.90.2.970 pmid:8044969 fatcat:isjc7atld5h57li5vsx6wqj7pe