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ADHESION MOLECULES AND INHERITED DISEASES OF THE HUMAN NERVOUS SYSTEM
Annual Review of Neuroscience
Mutations in the human genes for the adhesion molecules Po, L1, and merosin cause severe abnormalities in nervous system development. Po and merosin are required for normal myelination in the nervous system, and L1 is essential for development of major axon pathways such as the corticospinal tract and corpus callosum. While mutations that lead to a loss of the adhesive function of these molecules produce severe phenotypes, mutations that disrupt intracellular signals or intracellulardoi:10.1146/annurev.neuro.21.1.97 pmid:9530493 fatcat:ymnujsyse5fd7gt2fgo636u2zm