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Tyrosine 319 in the Interdomain B of ZAP-70 Is a Binding Site for the Src Homology 2 Domain of Lck
Journal of Biological Chemistry
T-cell antigen receptor-induced signaling requires both ZAP-70 and Lck protein-tyrosine kinases. One essential function of Lck in this process is to phosphorylate ZAP-70 and up-regulate its catalytic activity. We have previously shown that after T-cell antigen receptor stimulation, Lck binds to ZAP-70 via its Src homology 2 (SH2) domain (LckSH2) and, more recently, that Tyr 319 of ZAP-70 is phosphorylated in vivo and plays a positive regulatory role. Here, we investigated the possibility thatdoi:10.1074/jbc.274.20.14229 pmid:10318843 fatcat:twauargsqvcv7jnz2kihrw7a74